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李闯创课题组完成高难度明星分子Vinigrol的最短全合成 近日,我?;到淌诶畲炒纯翁庾樵诠识ゼ饣诳睹拦Щ嶂尽罚↗ournal of the American Chemical Society,简称JACS)发表论文,报道了明星天然产物Vinigrol的高效不对称全合成。
权泽卫课题组在《先进材料》发表重要研究进展 近日,南科大化学系教授权泽卫课题组在新型纳米金属间化合物领域取得最新进展,该成果发表在材料领域顶级期刊《先进材料》(Advanced Materials,IF:25.806)。
化学系徐晶课题组在《美国化学会志》发表成重要进展 近日,徐晶课题组再次在复杂笼状天然产物全合成领域取得重要进展,在《美国化学会志》发表重要研究论文,报道复杂笼状虎皮楠生物碱Caldaphnidine O的国际首次全合成。
化学系徐晶课题组在《美国化学会志》发表成果 近日,我?;蹈苯淌谛炀Э翁庾槌晒Φ赝瓿闪烁丛踊⑵ら锛頓apholdhamine B及其内酯衍生物的对映选择性全合成工作,相关研究成果在《美国化学会志》(J. Am. Chem. Soc.)上发表。
化学系刘心元课题组在自由基不对称化学领域取得重要研究进展 近日,我?;到淌诹跣脑翁庾樵诓欢猿铺绩C碳键偶联领域取得了重要研究进展。研究成果近期在《自然化学》(Nature Chemistry,IF:23.193)在线发表。
化学系黄文忠课题组在《美国化学会志》发表最新研究成果 近日,我?;蹈苯淌诨莆闹铱翁庾槌晒铣闪艘幌盗懈叻⒐馇慷鹊念?III)配合物,并首次将其应用于有机电致发光二极管,取得重要研究进展。该成果在国际顶尖化学期刊《美国化学会志》
【毕业季故事汇】 胡启锟:人称“胡博士”的科研达人
【毕业季故事汇】 尚琳瑛:化学女孩从南科大通往剑桥的逐梦之路

谭斌

副系主任、教授

化学系

0755-88018315

tanb@sustech.edu.cn

研究方向
不对称轴手性化学、催化不对称合成

谭斌是南方科技大学终身教授,化学系副主任、博士生导师。2001年本科毕业于湖南科技大学。2005年硕士毕业于厦门大学化学系。 2010年博士毕业于新加坡南洋理工大学化学与生物化学系,导师钟国富教授,研究方向为新型手性有机催化剂的设计及不对称多米诺反应的研究。2010年3月至2012 年9月的博士后期间,在有机小分子催化领域的发源地--美国斯克普斯研究所 (The Scripps Research Institute)师从Barbas教授,继续从事催化不对称合成的研究。2012年9月,以准聘(Tenure-Track)副教授身份加入南方科技大学化学系。2018年1月晋升为终身正教授。


到目前为止,在轴手性化学、不对称多组分反应、自由基化学以及协同催化领域发表高水平研究论文60多篇,其中包括以第一作者或通讯作者身份发表的1篇Science、2篇Nature Chemistry、3篇Nature Communications、 6篇J. Am. Chem. Soc.、11篇Angew. Chem. Int. Ed. 和1篇Accounts of Chemical Research,论文总被引超过4000次。多篇论文被多篇文章被不同国际杂志重点评述或被选为封面文章。此外还有多篇高水平研究论文正在审稿和准备之中。

目前担任《中国科学-化学》和《中国化学》青年编委。








2017年,2017中国新锐科技人物(知社学术圈)

2017年,Asian Core Program Lectureship Award (日本)

2016年,南方科技大学杰出科研奖

2016年,Asian Core Program Lectureship Award (新加坡)


◆ 轴手性化学:不对称催化与应用

◆ 有机催化不对称多组分反应的研究 

◆ 手性药物、手性材料的合成

1、国家自然科学基金委面上项目(64万)

轴手性苯乙烯衍生物的不对称合成与应用

 

2、手性螺环二酚的关键技术研发及其应用(80万)


 

3、深圳市科创委基础研究学科布局(300万)

含联芳抗菌药物关键问题研究

 

4、国家自然科学基金委面上项目(65万)

有机催化不对称合成联芳基轴手性化合物

 

5、深圳市科创委基础研究自由探索(30)

基于重氮吲哚酮的催化不对称合成及其产物的抗癌活性研究

 

6、国家自然科学基金委青年基金项目(25万)

不对称合成具有重要生物活性3,3′-四氢吡咯螺羟吲哚骨架结构

 

7、深圳市科创委基础研究自由探索(10万)

四氢吡咯螺羟吲哚衍生物的设计和催化不对称合成以及抗癌活性的研究

 

8、核心骨架结构导向的催化不对称合成(500+100万)


 

9、重大药物的绿色制备(200万)



代表性研究成果(2013年8月至今):


1.  Jian Zhang#, Peiyuan Yu#, Shao-Yu Li, He Sun, Shao-Hua Xiang,Jun (Joelle) Wang, Kendall N. Houk*, Bin Tan*. Asymmetric Phosphoric Acid-catalyzed Four-Component Ugi Reaction. Science 2018, 361, eaas8708. ( #equal contribution)


2.  Yong-Bin Wang, Bin Tan*. Construction of Axially Chiral Compounds via Asymmetric Organocatalysis. Acc. Chem. Res. 2018, 51, 534.


3.  Liang-Wen Qi#, Jian-Hui Mao#, Jian Zhang, Bin Tan*. Organocatalytic Asymmetric Arylation of Indoles Enabled by Azo Groups. Nat. Chem. 2018, 10, 58. ( #equal contribution)


4.  Yong-Bin Wang, Sheng-Cai Zheng, Yu-Mei Hu, Bin Tan*. Br?nsted Acid-Catalysed Enantioselective Construction of Axially Chiral Arylquinazolinones. Nat. Commun. 2017, 8, 15489.


5.  Sheng-Cai Zheng, San Wu, Yun-Hao Zhang, Liu Ye, Bin Tan*. Organocatalytic Atroposelective Synthesis of Axially Chiral Styrenes. Nat. Commun. 2017, 8, 15238.


6.  Lei Zhang, Jian Zhang, Ji Ma, Dao-Juan Cheng, Bin Tan*. Highly Atroposelective Synthesis of Arylpyrroles by Catalytic Asymmetric Paal-Knorr Reaction. J. Am. Chem. Soc. 2017, 139, 1714.


7.  Ye-Hui Chen, Liang-Wen Qi, Fang Fang, Bin Tan.* Organocatalytic Atroposelective Arylation of 2-Naphthylamines as a Practical Approach to Axially Chiral Biaryl Amino Alcohols. Angew. Chem. Int. Ed. 2017, 56, 16308.


8.  Shaoyu Li, Ji-Wei Zhang, Xian-Lin Li, Bin Tan*. Phosphoric Acid-Catalyzed Asymmetric Synthesis of SPINOL Derivatives. J. Am. Chem. Soc. 2016, 138, 16561.


9.  Jin-Hui Xu, Sheng-Cai. Zheng, Ji-Wei Zhang, Xin-Yuan Liu, Bin Tan*. Construction of Tropane Derivatives by Organocatalytic Asymmetric Dearomatization of Isoquinolines. Angew. Chem. Int. Ed. 2016, 55, 11834.


10.Ji-Wei Zhang, Jin-Hui Xu, Dao-Juan Cheng, Chuan Shi, Xin-Yuan Liu*, Bin Tan*. Discovery and Enantiocontrol of Axially Chiral Urazoles via Organocatalytic Tyrosine Click Reaction. Nat. Commun. 2016, 7, 10677.


11.Ye-Hui Chen, Dao-Juan Cheng, Jian Zhang, Yong Wang, Xin-Yuan Liu*, Bin Tan*. Atroposelective Synthesis of Axially Chiral Biaryldiols via Organocatalytic Arylation of 2?Naphthols. J. Am. Chem. Soc. 2015, 137, 15062.


12.Jian Zhang#, Shao-Xia Lin#, Dao-Juan Cheng, Xin-Yuan Liu*,  Bin Tan*. Phosphoric Acid-Catalyzed Asymmetric Classic Passerini Reaction. J. Am. Chem. Soc. 2015, 137, 14039. ( # equal contribution)


13.Ming-Yue Wu, Wei-Wei He, Xin-Yuan Liu*, Bin Tan*. Asymmetric Construction of Spirooxindoles by Organocatalytic Multicomponent Reactions Using Diazooxindoles. Angew. Chem. Int. Ed. 2015, 54, 9409.


14.Zhi-Jia Fang#, Sheng-Cai Zheng#, Zhen Guo, Jing-Yao Guo, Bin Tan,* Xin-Yuan Liu*. Asymmetric Synthesis of Axially Chiral Isoquinolones: Nickel-Catalyzed Denitrogenative Transannulation. Angew. Chem. Int. Ed. 2015, 54, 9528. ( #equal contribution)


15.Jin-Shun Lin, Peng Yu, Lin Huang, Pan Zhang, Bin Tan*, Xin-Yuan Liu*. Br?nsted Acid-Catalyzed Asymmetric Hydroamination of Alkenes: Synthesis of  Pyrrolidines Bearing a Tetrasubstituted Carbon Stereocenter. Angew. Chem. Int. Ed. 2015, 54, 7847.


16.Peng Yu, Sheng-Cai Zheng, Ning-Yuan Yang, Bin Tan*, Xin-Yuan Liu*. Phosphine-Catalyzed Remote β-C-H Functionalization of Amine Triggered by Trifluoromethylation of Alkenes: One-Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles. Angew. Chem. Int. Ed. 2015, 54, 4041.


17.Peng Yu, Jin-Shun Lin, Lei Li, Sheng-Cai Zheng, Ya-Ping Xiong, Li-Jiao Zhao, Bin Tan*, Xin-Yuan Liu*. Enantioselective C-H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene. Angew. Chem. Int. Ed. 2014, 53, 11890.


18.Dao-Juan Cheng, Liang Yan, Shi-Kai Tian*, Ming-Yue Wu, Lu-Xin Wang, Zi-Li Fan, Sheng-Cai Zheng, Xin-Yuan Liu*, Bin Tan*. Highly Enantioselective Kinetic Resolution of Axially Chiral BINAM Derivatives Catalyzed by a Br?nsted Acid. Angew. Chem. Int. Ed. 2014, 53, 3684.


19.Lin Huang, Jin-Shun Lin, Bin Tan*, Xin-Yuan Liu*. Alkene Trifluoromethylation-Initiated Remote α-Azidation of Carbonyl Compounds toward Trifluoromethyl γ-Lactam and Spirobenzofuranone-lactam. ACS Catal. 2015, 5, 2826.


20.Lin Huang, Sheng-Cai Zheng, Bin Tan*, Xin-Yuan Liu*, Metal-Free Direct 1,6- and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes. Org. Lett. 2015, 17, 1589.


21.Lin Huang, Sheng-Cai Zheng, Bin Tan*, Xin-Yuan Liu*, Trifluoromethylation-Initiated Remote Cross-Coupling of Carbonyl Compounds to Form Carbon-Heteroatom/Carbon Bonds. Chem. Eur. J. 2015, 21, 6718.


22.Lei Li, Jing-Yao Guo, Xing-Guo Liu, Su Chen, Yong Wang, Bin Tan*, Xin-Yuan Liu*. Amide Groups Switch Selectivity: C-H Trifluoromethylation of α,β-Unsaturated Amides and Subsequent Asymmetric Transformation. Org. Lett. 2014, 16, 6032.


23.Jin-Shun Lin, Xiang-Geng Liu, Xiao-Long Zhu, Bin Tan*, Xin-Yuan Liu*. Copper-Catalyzed Aminotrifluoromethylation of Unactivated Alkenes with TMSCF3: Construction of Trifluoromethylated Azaheterocycles. J. Org. Chem. 2014, 79, 7084.


24.Xing-Li Zhu, Jin-Hui Xu, Dao-Juan Cheng, Li-Jiao Zhao, Xin-Yuan Liu*, Bin Tan*. In Situ Generation of Electrophilic Trifluoromethylthio Reagents for Enantioselective Trifluoromethylthiolation of Oxindoles. Org. Lett. 2014, 16, 2192.


25.Ya-Ping Xiong, Ming-Yue Wu, Xiang-Yu Zhang, Can-Liang Ma, Lin Huang, Li-Jiao Zhao, Bin Tan*, Xin-Yuan Liu*. Direct Access to α-CF3-enones via Efficient Copper-Catalyzed Trifluoromethylation of Meyer-Schuster Rearrangement. Org. Lett. 2014, 16, 1000.


26.Lei Li, Min Deng, Sheng-Cai Zheng, Ya-Ping Xiong, Bin Tan*, Xin-Yuan Liu*. Metal-Free Direct Intramolecular Carbotrifluoromethylation of Alkenes to Functionalized Trifluoromethyl Azaheterocycles. Org. Lett. 2014, 16, 504.


27.Jin-Shun Lin, Ya-Ping Xiong, Can-Liang Ma, Li-Jiao Zhao, Bin Tan*, Xin-Yuan Liu*. Efficient Copper-Catalyzed Direct Intramolecular Aminotrifluoromethylation of Unactivated Alkenes with Diverse Nitrogen-Based Nucleophiles. Chem. Eur. J. 2014, 20, 1332.


28.Dao-Juan Cheng, Yoshihiro Ishihara, Bin Tan*, Carlos F. Barbas, III*. Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies. ACS Catal. 2014, 4, 743.


代表性研究成果(独立工作以前):


1.  Tan. B.; Toda N; Barbas III, C. F. Organocatalytic Amidation and Esterification of Aldehydes with Activating Reagents by a Cross-coupling Strategy. Angew. Chem. Int. Ed. 2012, 51, 12538.


2.  Tan. B.; Hernández-Torres, G.; Barbas III, C. F. Rationally Designed Amide Donors for Organocatalytic Asymmetric Michael Reactions. Angew. Chem. Int. Ed. 2012, 51, 5381.


3.  Tan, B.; Candeias, N.; Barbas III, C. F. Construction of Bispirooxindoles Containing three Quaternary Stereocentres in a Cascade Using a Single Multifunctional Organocatalyst. Nat. Chem. 2011, 3, 473.


4.  Tan B.; Hernández-Torres, G.; Barbas III, C. F. Highly Efficient Hydrogen-Bonding Catalysis of the Diels-Alder Reaction of 3-Vinylindoles and Methyleneindolinones Provides Carbazolespirooxindole Skeleton. J. Am. Chem. Soc. 2011, 133, 12354.


5.  Tan, B.; Candeias, N.; Barbas III, C. F. Core-Structure-Motivated Design of a Phosphine-Catalyzed [3+2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles. J. Am. Chem. Soc. 2011, 133, 4672.


6.  Tan, B.; Shi. Z.; Chua, P. J.; Li, Y.; Zhong, G. Unusual Domino Michael/Aldol Condensation Reactions Employing Oximes as N-Selective Nucleophiles: Synthesis of N-Hydroxypyrroles. Angew. Chem. Int. Ed. 2009, 48, 758.







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