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李闯创课题组完成高难度明星分子Vinigrol的最短全合成 近日,我?;到淌诶畲炒纯翁庾樵诠识ゼ饣诳睹拦Щ嶂尽罚↗ournal of the American Chemical Society,简称JACS)发表论文,报道了明星天然产物Vinigrol的高效不对称全合成。
权泽卫课题组在《先进材料》发表重要研究进展 近日,南科大化学系教授权泽卫课题组在新型纳米金属间化合物领域取得最新进展,该成果发表在材料领域顶级期刊《先进材料》(Advanced Materials,IF:25.806)。
化学系徐晶课题组在《美国化学会志》发表成重要进展 近日,徐晶课题组再次在复杂笼状天然产物全合成领域取得重要进展,在《美国化学会志》发表重要研究论文,报道复杂笼状虎皮楠生物碱Caldaphnidine O的国际首次全合成。
化学系徐晶课题组在《美国化学会志》发表成果 近日,我?;蹈苯淌谛炀Э翁庾槌晒Φ赝瓿闪烁丛踊⑵ら锛頓apholdhamine B及其内酯衍生物的对映选择性全合成工作,相关研究成果在《美国化学会志》(J. Am. Chem. Soc.)上发表。
化学系刘心元课题组在自由基不对称化学领域取得重要研究进展 近日,我?;到淌诹跣脑翁庾樵诓欢猿铺绩C碳键偶联领域取得了重要研究进展。研究成果近期在《自然化学》(Nature Chemistry,IF:23.193)在线发表。
化学系黄文忠课题组在《美国化学会志》发表最新研究成果 近日,我?;蹈苯淌诨莆闹铱翁庾槌晒铣闪艘幌盗懈叻⒐馇慷鹊念?III)配合物,并首次将其应用于有机电致发光二极管,取得重要研究进展。该成果在国际顶尖化学期刊《美国化学会志》
【毕业季故事汇】 胡启锟:人称“胡博士”的科研达人
【毕业季故事汇】 尚琳瑛:化学女孩从南科大通往剑桥的逐梦之路

何振宇

副教授

化学系

0755-88018318

jasonhcy@sustech.edu.cn

研究方向
金属有机催化应用研究
Dr. Chun-Yu Ho received his Ph.D. in 2005 under the supervision of Prof. Dan Yang in The University of Hong Kong for organocatalytic asymmetric epoxidation. After pursing post-doctoral research during 2005-07 with Prof. Timothy F. Jamison in MIT for transition metal catalysis, he started his independent career at The Chinese University of Hong Kong (CUHK) as a Research Assistant Professor at the end of 2007. Now he is Associate Professor in Southern University of Science and Technology in 2013 and Honorary AP of CUHK. He is the recipient of The Croucher Foundation Fellowship of Hong Kong, Asian Core Program Lectureship Award from both Japan in 2010 and Singapore in 2011, recognized as Overseas High-Caliber Personnel from Shenzhen in 2013, and awarded ACS Excellence in Science Symposium: The Journal of Organic Chemistry and Organic Letters Best Poster in 2013.
2005-07 The Croucher Foundation Fellowship Award
2010-11 The Asian Core Program Lectureship Award (from Japan)
2011-12 The Asian Core Program Lectureship Award (from Singapore)
2012 Publication honored in RSC Chem. Commun. 2012 Emerging Investigator Issue
2012 One of the three invited oversea lecturers in 3rd Symposium of Molecular Activation
Directed toward Straightforward Synthesis, at Hanamaki, Iwate (MEXT, Japan)
2012 Adjunct AP at Southern University of Science and Technology
2013 Adjunct AP at The Chinese University of Hong Kong
2013 Editorial Member of Natural Products Chemistry & Research Journal
2013 Recognized as Overseas High-Caliber Personnel (Peacock Program Awardee from
Shenzhen Government) 深圳市孔雀计划 B 类人员
2013 Presentation in ISORM, a Celebration in Honor of Grubbs, Houk, Schleyer & Truhlar
2013 ACS Excellence in Science Symposium: The Journal of Organic Chemistry and Organic
Letters Best Poster Award
2014 Invited Contribution in Synlett Special Issue:
Catalysis with Sustainable Metals (1 of 18 papers)
2014 Invited Contribution in J. Org. Chem. Special Issue:
Mechanisms in Metal-Based Organic Chemistry (1 of 37 papers from 14 countries)
2015 Paper recognized as very important paper in the area of N-Heterocyclic Carbene (VIP)
and Front Cover Story in Angew. Chem. Int. Ed.
Develop novel, practical, green and energy efficient methods for:
1. Organic chemical library synthesis;
2. Sustainable organic/hybrid materials preparations and applications;
3. Phosphonylation and cyanation to access important biological compounds and their
subsequent SAR studies.
A/ US Non-Provisional Patent granted or filed (As the sole inventor):
1. Ho, C.-Y. US8354554B2 “Process for Preparing Organometalloids”
2. Ho, C.-Y. US8383873B2 “Terminal 1,1-Disubstituted Olefin, Methods of Making & Using
Thereof”
3. Ho, C.-Y. US regular patent filed, application number: 13/415304, title remains confidential
4. Ho, C.-Y. PCT filed, application number: PCT/CN2014/082861, “Process for Preparing
Branched Allyl Compounds”
5. Ho, C.-Y. PCT filed, application number: PCT/CN2015/071187, title remains confidential
B/ Invited Review (As corresponding author):
1. “NHC-Ni-H Reactions with Simple Olefins: Advances in Hydroalkenylation, Polymerization, and
Ionic Liquid Synthesis.”
Ho, C.-Y.*; He, L.; Chan, C.-W. Synlett 2011, SynPacts issue, 1649.
2. “Catalytic Addition of Simple Alkenes to Carbonyl Compounds Using Group 10 Metals”
Ho, C.-Y.*; Schleicher, K. D.; Chan, C.-W.; Jamison, T. F.* Synlett 2009, 2565.
C/ Book Chapter:
1. “NHC-Ni Hydride Catalyzed Terminal Disubstituted Alkene Synthesis”
Ho, C.-Y.*; He, L. ISBN 978-3-8465-0051-4, 88pgs.
2. “Introduction to General, Organic and Biological Chemistry” Global Edition
D/ Paper (Since 2005):
a/ Catalysis having C-C Bond Formation
1. “Catalytic Asymmetric Hydroalkenylation of Vinylarenes: Electronic Effects of Substrates and
Chiral N-Heterocyclic Carbene Ligands”
Ho, C.-Y.*; Chan, C.-W.; He, L. Angew. Chem. Int. Ed. 2015, 54, 4512.
Highlighted thrice:
Featured as Front Cover & VIP (Very Important Paper),
in Angew. Chem. Int. Ed. 2015, 54 (15), 4403.
in ChemCatChem 2015, 7, 1639 by Prof. Gerhard Hilt &
in X-Mol on 2015-04-17
2. “Substituted 1,3-cyclohexadiene synthesis by NHC-Nickel(0) catalyzed [2+2+2] cycloaddition of
1,n-Enyne”
Zhao, J.-P.; Chan, S.-C.; Ho, C.-Y.* Tetrahedron 2015, 71, 4426.
Invited Special Symposium-in-Print: Progress in organic synthesis: New reactions,
strategies and targets.
3. “Medium-Sized Heterocycle Synthesis by the Use of Synergistic Effects of Ni-NHC and γ
Coordination in Cycloisomerization.”
Ho, C.-Y.*; He, L. J. Org. Chem. 2014, 79, 11873.
Invited Special Issue:
(1 of 37 from over 14 countries)
Highlighted twice:
SynFacts 2014, 10, 913 (by Prof. V. Snieckus)
Organic Chemistry Highlights, 2015, (by Prof. D. F. Taber)
“C-O Ring Construction”.
4. “Nitrate-Enhanced NHC-NiH Catalyzed Tail-to-Tail Vinyl Ether Dimerization.”
He, L.; Ho, C.-Y.* Synlett 2014, 25, 2738.
Invited Special Issue: Catalysis with Sustainable Metals. (1 of 18 papers)
5. “Shuffle off the Classic β-Si Elimination by Ni-NHC Cooperation:
Implication for C-C Forming Reactions Involving Ni-Alkyl-β-Silanes.”
Ho, C.-Y.*; He, L. Chem. Commun. 2012, 48, 1481.
Honored in Emerging Investigator Issue (1 of 71 papers in the year)
Has been recommended on PubMed advanced by Novo Nordisk®
6. “Catalytic Intermolecular Tail-to-Tail Hydroalkenylation of Styrenes with alpha Olefins:
Regioselective Migratory Insertion Controlled by a Nickel/N-Heterocyclic Carbene.”
Ho, C.-Y.*; He, L. Angew. Chem. Int. Ed. 2010, 49, 9182.
Highlighted thrice:
SynForm 2011, issue 2, A15-16 & as Cover (by Prof. M. Zanda);
SynFacts 2011, issue 3, 310 (by Prof. P. Knochel);
Organic Chemistry Highlights, 2011 (by Prof. D. F. Taber)
“Functionalization & Homologation of Alkenes”.
7. “Cyanative Alkene-Aldehyde Coupling: Ni(0)-NHC-Et2AlCN Mediated Chromanols Synthesis with High cis-Selectivity at room temperature.” Ho, C.-Y.* Chem. Commun. 2010, 46, 466.
8. “Nitrile assisted, Bronsted acid catalyzed regio and stereoselective diarylphosphonylation of allyl silyl ethers.”
Ho, C.-Y.*; Chan, C.-W.; Wo, S.-K.; Zuo, Z.; Chan, L.-Y. Org. Biomol. Chem. 2010, 8, 3480.
9. “Alpha Olefins as Alkenylmetal Equivalents in Catalytic Conjugate Addition Reactions.”
Ho, C.-Y.; Ohmiya, H.; Jamison, T. F.* Angew. Chem. Int. Ed. 2008, 47, 1893.
10. “Highly Selective Coupling of Alkenes and Aldehydes Catalyzed by NHC–Ni–P(OPh)3: Synergy
Between a Strong σ-Donor and a Strong π-Acceptor.”( Hot Paper)
Ho, C.-Y.; Jamison, T. F.* Angew. Chem. Int. Ed. 2007, 46, 782.
11. “Nickel-Catalyzed Coupling of Alkenes, Aldehydes, and Silyl Triflates.”
Ng, S.-S.; Ho, C.-Y.; Jamison, T. F.* J. Am. Chem. Soc. 2006, 128, 11513.
12. “Nickel-Catalyzed, Carbonyl-Ene-Type Reactions: Selective for Alpha Olefins and More Efficient
with Electron-Rich Aldehydes.”
Ho, C.-Y.; Ng, S.-S.; Jamison, T. F.* J. Am. Chem. Soc. 2006, 128, 5326.
b/ Catalysis having C-Heteroatom Bond Formation
1. “Highly Chemoselective Reductive Amination of Carbonyl Compounds Promoted by
InCl3/Et3SiH/MeOH System.”
Lee, O.-Y.; Law, K.-L.; Ho, C.-Y.; Yang, D.* J. Org. Chem. 2008, 73, 8829.
2. “Fluorinated Chiral Secondary Amines as Catalysts for Epoxidation of Olefins with Oxone.”
Ho, C.-Y.; Chen, Y.-C.; Wong, M.-K.; Yang, D.* J. Org. Chem. 2005, 70, 898.
c/ Collaborative Pharmaceutical Research Papers Published:
1. "Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as
acetylcholinesterase inhibitors."
Qian, S.; He, L.; Mak, M.; Han, Y.; Ho, C.-Y.*; Zuo, Z.* Int. J. Pharmaceutics, 2014, 477, 442.
2. "In Vitro Anti-acetylcholinesterase Activities and Permeabilities of Novel Potential Anti-Alzheimer's Agents".
Qian, S.; Mak, M.; He, L.; Ho, C.-Y.*; Han, Y.*; Zuo, Z.*
Paper presented in the 9th International ISSX Meeting, organized by International Society for the Study of Xenobiotics, 1 pgs. Istanbul, Turkey, 2010.09.04.
3. "Structure-activity and structure-permeability relationships of novel anti-Alzheimer’s agents tacrine dimers".
Qian, S.; He, L.; Mak, M.; Ho, C.-Y.*; Han, Y.*; Zuo, Z.* Paper presented in the 2011 AAPS Annual Meeting and Exposition, organized by The American Association of Pharmaceutical Scientists, 1 pgs. Washington, DC, USA, 2011.10.26.
4. "Development of LC/MS/MS method for determination of a novel tacrine dimer HLS-3 in rat plasma and its application to pharmacokinetic study".
Qian, S.; He, L.; Wo, S-K.; Mak, M.; Han, Y.*; Ho, C-Y.*; Zuo, Z.* Paper presented in the 2012 AAPS Annual Meeting and Exposition, organized by The American Association of Pharmaceutical Scientists, USA, 2012.10.14.

Professional Services:
* Serve as reviewer of the following journals:
Angewandte Chemie International Edition
Chemistry An Asian Journal
Chemistry An European Journal
Journal of the American Chemical Society (JACS)
Journal of Organometallic Chemistry
Organic Letters
Organic and Biomolecular Chemistry
RSC Advance
Synthesis
Synlett
* Serve as an Editorial member of the Journal below:
Natural Products Chemistry & Research Journal

Graduate Students Training
Awards the Trained Graduate Students Received in our Group:
* 1 Asian Core Program (ACP), Junior Workshop on Cutting-Edge Organic Chemistry in Asia Poster Award (2010).
* 1 Hong Kong Graduate Symposium Poster Award (Organic Chemistry Section).
Awarded by Hong Kong Graduate Symposium Committee (2011)
* 1 Hong Kong PhD Fellowship. Awarded by UGC (2011)
* 1 Student awarded Madam Wong Siew Khoon Scholarship, nominated by the Science Faculty Scholarship Committee as CUHK representative (2012).
* 1 Student awarded Faculty of Science Postgraduate Student Research Output Award (2012, one Award in each year).
Professional Services:
* Serve as reviewer of the following journals:
Angewandte Chemie International Edition
Chemistry An Asian Journal
Chemistry An European Journal
Journal of the American Chemical Society (JACS)
Journal of Organometallic Chemistry
Organic Letters
Organic and Biomolecular Chemistry
RSC Advance
Synthesis
Synlett
* Serve as an Editorial member of the Journal below:
Natural Products Chemistry & Research Journal

Graduate Students Training
Awards the Trained Graduate Students Received in our Group:
* 1 Asian Core Program (ACP), Junior Workshop on Cutting-Edge Organic Chemistry in Asia Poster Award (2010).
* 1 Hong Kong Graduate Symposium Poster Award (Organic Chemistry Section).
Awarded by Hong Kong Graduate Symposium Committee (2011)
* 1 Hong Kong PhD Fellowship. Awarded by UGC (2011)
* 1 Student awarded Madam Wong Siew Khoon Scholarship, nominated by the Science Faculty Scholarship Committee as CUHK representative (2012).
* 1 Student awarded Faculty of Science Postgraduate Student Research Output Award (2012, one Award in each year).
? 2015 All Rights Reserved. 粤ICP备14051456号 地址:广东省深圳市南山区学苑大道1088号 电话:+86-755-8801 0000 邮编:518055
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